Example of an automated tumor segmentation in a mouse using Definiens' Developer XD software.
On the left, a volume rendering of the mouse torso (CT in grayscale, SPECT in NIH Fire 2) is shown, while on the right hand side, the tumor was isolated using inviCRO's digital scalpel tool.

The segmentation rule set provided by the Boston-based contract research organization finds the tumor based on its characteristics in the anatomical CT only. This approach not only allows a very precise volume measurement (including necrotic parts of the tumor), but also delivers highly consistent estimates of the tumor uptake from the SPECT image. SPECT and CT images generated on Bioscan's NanoSPECT/CT.

Please note, that different SPECT color scales where used in the left and right movie.

Special thanks to Dr. Hesterman (Bioscan) for his support in data pre-processing and image generation. The mouse image is courtesy of Ben Gershman (Univ. New Mexico).