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Show NanoSPECT studies: All

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Triple Modality Rat Study (MR, SPECT, CT; slices)

inviCRO, Boston | Rat, SPECT/CT, MRI, I-125

		Comments
		Transverse slices from a tri-modality study (MRI, SPECT, CT) of a rat brain acquired at the Center for Translational Neuroimaging in the newly created imaging facility at Northeastern University. The MRI (grayscale, 100umx100umx500um, 30min acq.) was acquired on a 7T Bruker magnet using a spin-echo sequence (RARE) comprised of 50 slices with 6 averages. The SPECT (green, 600um voxels, 30min acq.) and CT (NIH Fire2, 400um voxels, 4.5min acq.) images were generated on a NanoSPECT/CT. 400 uCi of I125-beta-CIT (a dopamine and serotonin transporter imaging agent) was injected 4.5 hours prior to the SPECT study. Tracer localized in eyes, striatum and thyroid. Animal was imaged on a Minerve bed under isoflurane. Data registration and presentation supported by inviCRO. [Tracer Details]
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Automatic Biodistribution from inviCRO (Rendering powered by Definiens)

inviCRO, Boston | Mouse, SPECT/CT, Tc-99m, Animation, Segmentation

		Comments
		Displayed: Image rendering of an automated 3D segmentation of a dual-modality study from the NanoSPECT/CT (Tc99m-Glucarate on a tumor bearing mouse; early stage) using the Definiens Developer XD software platform. The relevant color-coded organs shown in the animation were segmented and classified using a step-wise Rule Set specific to 3D SPECT-CT image acquisitions. The above movie was generated as a collaborative effort between Definiens, inviCRO and Bioscan.
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Automatic Biodistribution from inviCRO (powered by Definiens)

inviCRO, Boston | Mouse, SPECT/CT, Tc-99m, Animation, Segmentation

		Comments
		Displayed: On the left-hand side is a standard maximum intensity projection (MIP) of a study performed on a NanoSPECT/CT of Tc99m-Glucarate in a mouse with a very early stage tumor. The image on the right-hand side is also a MIP, however instead of a standard SPECT image the data set co-registered with the CT was generated by assigning integer values to organs automatically segmented using the Definiens Developer XD software platform. The data set was classified using a step-wise Rule Set specific to 3D SPECT-CT image acquisitions. The above movie was generated as a collaborative effort between Definiens, inviCRO and Bioscan.
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Inhalant aerosol imaging in a rat (R1)

University of New Mexico | Rat, SPECT/CT, Tc-99m

		Comments
		Specialized equipment was used to administer a colloidal inhalant aerosol to a mouse. Exposure to the aerosol was limited to three minutes, immediately prior to imaging. Estimated dose is ~350uCi (12MBq), although the administration method complicates the dose estimation procedure. Whole-body image data were acquired for 23 minutes (24 projections, 44 seconds per projection), using a standard, whole-body, high-sensitivity aperture. Whole-body CT data were acquired over 10 minutes (180 projections/rotation, 1 second per projection). Images courtesy of Lovelace Respiratory Research Institute and Ben Gershman, University of New Mexico
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Quantitative lung capacity evaluation in a gravid lizard

University of New Mexico | Other Species, CT only, Segmentation

		Comments
		A CT study was performed to quantify the reduction in usable lung capacity in a lizard as a result of gravidity. CT data were acquired late in the gravidity of the lizard and again immediately after the laying of the eggs. Whole-body, six-minute (180 projections/rotation, 1 second per projection) acquisitions were performed in both cases. In the image, the chart displays the quantified change in lung volume (a series of 8-slice, anatomically-based, sub-regions of the lung were used for overall lung volume estimation) as a function of gravidity. The image on the right displays the lung region of the lizard in a gravid state while the imaging the left displays the lung region of the same animal post-gravidity. Images courtesy of Casey Gilman & Ben Gershman, University of New Mexico
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Cardiac Gating with Human Serum Albumin (HSA)

NKI-AvL, Amsterdam | Mouse, SPECT/CT, Dynamic/Gated, Tc-99m

		Comments
		A mouse was injected via tail vein with ~35 MBq (< 1mCi) of Tc-labeled human serum albumin (HSA). Imaging began immediately (~2 minutes) post-injection. Two acquisitions (one 16-minutes and one 32-minutes) were performed in succession. Projection data from the two acquisitions were combined (via the IVS Sum Projections tool). Eight frames were used for the gating. Mouse cardiac rate was stable and between 250-300 BPM for the duration of the acquisition. Images courtesy of Dr. Fijs van Leeuwen at the National Cancer Institute, Amsterdam, Netherlands (NKI-AVL)
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Respiratory Gating with macro aggregate albumin (MAA)

NKI-AvL, Amsterdam | Mouse, SPECT/CT, Dynamic/Gated, Tc-99m

		Comments
		Bioscan's Featured Study of the 4th Quarter: A mouse was injected with ~19MBq (~0.5mCi) of Tc99m-labeled macro-aggregated albumin (MAA). Imaging was performed 60 minutes post-injection. Respiratory gating was performed using an external box from SA Instruments. A small pneumatic pillow is used to detect respiration Data were acquired over 12 minutes, using 6 frames. Respiratory rates were stable and around 130 BPM throughout the acquisition. Images courtesy of Dr. Fijs van Leeuwen at the National Cancer Institute, Amsterdam, Netherlands (NKI-AVL).
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Cardiac-gated mouse heart

Mediso, Ltd. | Mouse, SPECT only, Dynamic/Gated, Tc-99m

		Comments
		A scout CT scan was collected to pinpoint the heart and liver location in a mouse (maximizing efficiency) injected with Tc^99m-labeled MIBI. The animal was anesthetized with sodium pentobarbitol (Nembutol). Focused cardiac-gated (ECG) heart/liver data were acquired with 24 projections collected over an 18mm scan range using 4 apertures equipped with 9 pinholes of 1.4mm diameter (allowing a resolution down to 1.1 mm). Count rates (heart and liver) were approximately 2500 cps. The heart rate was >200 bpm with the cardiac cycle divided into 8 frames. Special thanks to Dr. Jacob Hesterman for imaging and post-processing, and Dr. Domokos Mathe for the animal handling. [Tracer Details]
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I-131 Mouse Tumor Study (Longitudinal: 19h, 168h, 456h p.i.)

University of New Mexico | Mouse, SPECT/CT, Dynamic/Gated, I-131

		Comments
		Longitudinal tumor study in a mouse using I¹³¹ (8d phys. half life, 364 keV peak) labeled I¹³¹-CLR1404 (a radioiodinated phospholipid ether analog), imaged 19 hours (left) and 7 days (middle) and 19 days (right) post injection. At times of acquisition, the mouse contained as little as 11 MBq (300 µCi) of I¹³¹. However, even weeks later, the uptake in the tumor is still clearly detectable, thus allowing for longitudinal studies, tracking the development of tumors in individual animals. Despite the high energy of the I¹³¹ photons and the low activity, there is a strong signal of the tumor visible in all images. In the right image, a post-processing smoothing filter was applied (Gauss, 2 mm FWHM). For more details on the tracer see: http://cellectar.com/sciences/ Imaged at the UNM for Cellectar, LLC
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Respiratory Gated Mouse (All views)

University of New Mexico | Mouse, SPECT only, Dynamic/Gated, Tc-99m

		Comments
		Respiratory gated scan of the torso of a mouse, showing liver, gallbladder and kidneys. Visible are a (M)aximum Intensity Projection, (C)oronal, (S)agittal and (T)ransversal views. Imaging parameters: 2mCi of Tc^99m-labeled MIBI imaged 45 minutes post injection in a 32 minute acquisition. Special thanks to Ben Gershman and Jacob Hesterman for image acquisition and post-processing. [Tracer Details]
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