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Mouse Fullbody CT (rendering, rotating)

SPECT-CT.com | Mouse, CT only

		Comments
		Volume rendered full-body animation of a reconstructed mouse.
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Mouse Cranium CT (rendering, rotating)

SPECT-CT.com | Mouse, CT only

		Comments
		Animation of a volume rendered mouse head produced by a CT scan.
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Quintuple Image Co-Registration (Checkerboard)

inviCRO, Boston | Rat, SPECT/CT, Tc-99m, I-123, In-111, Tl-201, Animation

		Comments
		A quadruple isotope SPECT/CT imaging acquisition was performed on a rat. 450uCi (17MBq) of Tc^99m-MDP, 1.4mCi (52MBq) of I¹²³, 600uCi (22MBq) of In¹¹¹, and 1mCi (37MBq) of Tl²⁰¹-Chloride were administered to the rat. A 40-minute image acquisition was performed at 3 hours post-injection of the Tc^99m/I¹²³ and 1 hour post-injection of the In¹¹¹/Tl²⁰¹. The color bars from left to right are: CT, Tc^99m, I¹²³, In¹¹¹ and Tl²⁰¹. Please see [158] for more details. Data courtesy of the University of New Mexico College of Pharmacy.
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High-resolution CT imaging of microcalcification of breast cancer (var. res.)

Frangioni Lab./Longwood SAIF | Mouse, CT only

		Comments
		Displayed is high-resolution ex vivo image of microcalcification of breast cancer. Please see [159] for details. In this figure, the results of reconstructing with various voxel sizes of 10µm, 100µm, 200µm and 400µm are shown. The increase in resolvable structures shows that using very small pixel sizes is worth the computational effort when looking for high-resolution applications. The image is courtesy the Frangioni Laboratory, Longwood SAIF, Harvard Medical school.
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CT Imaging of Tumor Vasculature (Volume rendering)

Queen Mary's, London | Mouse, CT only, Enhanced CT, Segmentation

		Comments
		A two-part image is presented displaying the results of whole-body and focused CT imaging of vasculature in a mouse. Imaging was performed after introduction of MICROFIL, a radio-opaque compound, to the vasculature system. Whole-body image data were acquired in 12 minutes. Crosshairs indicate the location of the tumor on the left shoulder. After excision, the tumor (17mm axial extent) was re-imaged in 9 minutes. Cone-beam filtered back projection with a Shepp Logan filter and 50-micron voxels was chosen for reconstruction. Maximum intensity projection: [150] Slice view of entire mouse: [152]
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CT Imaging of Tumor Vasculature (Slice view)

Queen Mary's, London | Mouse, CT only, Enhanced CT

		Comments
		A two-part image is presented displaying the results of whole-body and focused CT imaging of vasculature in a mouse. Imaging was performed after introduction of MICROFIL, a radio-opaque compound, to the vasculature system. Whole-body image data were acquired in 12 minutes. Crosshairs indicate the location of the tumor on the left shoulder. After excision, the tumor (17mm axial extent) was re-imaged in 9 minutes. Cone-beam filtered back projection with a Shepp Logan filter and 50-micron voxels was chosen for reconstruction. Maximum intensity projection: [150] Volume rendering: [151]
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Aerosol lung deposition in a mouse (MIP rendering)

CNRS, Orleans | Mouse, SPECT/CT, Tc-99m

		Comments
		Approximately 150uCi (in 50uL) of stannous colloids labeled with Tc-99m were nebulized into the lungs of a normal FVB mouse with a microsprayer. Image data were acquired using a high-resolution, whole body multi-pinhole (9) aperture over 18 minutes, beginning approximately 15 minutes post-administration. A fully 3D volume rendering of the SPECT/CT data is shown in [145]. Images courtesy of Alain Le Pape, CNRS, Orleans, France
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Triple Modality Rat Study (MR, SPECT, CT; MIP)

inviCRO, Boston | Rat, SPECT/CT, MRI, I-125

		Comments
		Maximum intensity projections from a tri-modality study (MRI, SPECT, CT) of a rat brain acquired at the Center for Translational Neuroimaging in the newly created imaging facility at Northeastern University. The MRI (grayscale, 100umx100umx500um, 30min acq.) was acquired on a 7T Bruker magnet using a spin-echo sequence (RARE) comprised of 50 slices with 6 averages. The SPECT (green, 600um voxels, 30min acq.) and CT (NIH Fire2, 400um voxels, 4.5min acq.) images were generated on a NanoSPECT/CT. 400 uCi of I125-beta-CIT (a dopamine and serotonin transporter imaging agent) was injected 4.5 hours prior to the SPECT study. Animal was imaged on a Minerve bed under isoflurane. Data registration and presentation supported by inviCRO. [Tracer Details]
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Automatic Biodistribution from inviCRO (Classifications, powered by Definiens)

inviCRO, Boston | Mouse, SPECT/CT, Tc-99m, Animation, Segmentation

		Comments
		The animation shows the classification of a SPECT/CT scan in which the visibility of classes is switched on and off in a circle. Please see [135] for further details.
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Inhalant aerosol imaging in a mouse (M1)

University of New Mexico | Mouse, SPECT/CT, Tc-99m

		Comments
		Specialized equipment was used to administer a colloidal inhalant aerosol to a mouse. Exposure to the aerosol was limited to three minutes, immediately prior to imaging. Estimated dose is ~150uCi (5-6MBq), although the administration method complicates the dose estimation procedure. Whole-body image data were acquired for 30 minutes (24 projections, 100 seconds per projection), using a standard, whole-body, high-sensitivity aperture. Whole-body CT data were acquired over 6 minutes (180 projections/rotation, 1 second per projection). Images courtesy of Ben Gershman, University of New Mexico
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