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SPECT-CT imaging of small peritoneal carcinomatosis.

IRCMontpellier | Mouse, SPECT/CT, I-125

		Comments
		We previously assessed the efficiency of intravenous injections of 125I-labeled mAbs for the treatment of small peritoneal carcinomatosis (Santoro et al, J. Nucl Med 2009). In the present study, athymic nude mice bearing intraperitoneal A-431 tumor cell xenografts expressing CEA receptors were intraperitoneally injected with 125I-35A7 mAb at days 4 following tumor cells xenograft. SPECT-CT imaging shows strong uptake of 125I-mAbs by tumors nodules, and demonstrates its usefulness for radioimmunotherapy of small solid tumors. Tracer details : The non-internalizing murine IgG1k 35A7 mAb, specific for the CEA Gold 2 epitope, was used to target CEA in transfected A-431 cells. Radiolabeling with iodine 125 was done according to the IODO-GEN method. Contributor : Jean-Pierre Pouget, IRCM
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Quintuple Image Co-Registration

inviCRO, Boston | Rat, SPECT/CT, Tc-99m, I-123, In-111, Tl-201, Animation

		Comments
		A quadruple isotope SPECT/CT imaging acquisition was performed on a rat. 450uCi (17MBq) of Tc^99m-MDP, 1.4mCi (52MBq) of I¹²³, 600uCi (22MBq) of In¹¹¹, and 1mCi (37MBq) of Tl²⁰¹-Chloride were administered to the rat. A 40-minute image acquisition was performed at 3 hours post-injection of the Tc^99m/I¹²³ and 1 hour post-injection of the In¹¹¹/Tl²⁰¹. The color bars from left to right are: CT, Tc^99m, I¹²³, In¹¹¹ and Tl²⁰¹. Please see [158] for more details. Data courtesy of the University of New Mexico College of Pharmacy.
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Inflammation imaging in ferrets

University of New Mexico | Other Species, SPECT/CT, In-111

		Comments
		A cohort of ferrets was induced with the flu in an attempt to visualize uptake of radiotracer in the sinuses. In this trial experiment 590uCi of In-111 (green) labeled with an inflammation targeting agent were injected. A fast, 7-minute CT acquisition was acquired over a 230mm scan range followed by a 20-minute SPECT acquisition. In-111 uptake in the trachea, heart, and lymphatic regions is clearly visible. Note also the striations visible in the ferret's trachea. Images courtesy of the University of New Mexico, College of Pharmacy, and the Lovelace Respiratory Research Institute.
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Dual-Isotope ECG-Gated SPECT/CT of a Rat

University of New Mexico | Rat, SPECT/CT, Dual-Isotope, Dynamic/Gated, Tc-99m, Tl-201, Animation

		Comments
		Dual-isotope ECG-gated SPECT/CT imaging was performed on a rat. 800uCi (30MBq) of Tc^99m-SestaMIBI and 970uCi (36MBq) of Tl²⁰¹-Chloride were injected into a rat. Data were acquired for 45 minutes at 60 minutes post-injection. Average heart rate was stable at ~320 BPM with the rat held under gas anesthesia. The image presents Tc^99m+CT data on the left and Tl²⁰¹+CT data on the right. Images courtesy of the University of New Mexico. [Tracer Details]
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Quadruple-isotope imaging in a rat

University of New Mexico | Rat, SPECT only, Dual-Isotope, Tc-99m, I-123, In-111, Tl-201

		Comments
		A quadruple isotope SPECT/CT imaging acquisition was performed on a rat. 450uCi (17MBq) of Tc^99m-MDP, 1.4mCi (52MBq) of I¹²³, 600uCi (22MBq) of In¹¹¹, and 1mCi (37MBq) of Tl²⁰¹-Chloride were administered to the rat. A 40-minute image acquisition was performed at 3 hours post-injection of the Tc^99m/I¹²³ and 1 hour post-injection of the In¹¹¹/Tl²⁰¹. From left to right, the image displays reconstructions of Tc^99m (gray; bone uptake), I¹²³ (purple; thyroid and small intestine uptake), In¹¹¹ (blue; heart, liver, and intestine uptake), and Tl²⁰¹ (red; kidney, liver, and heart uptake). Images courtesy of the University of New Mexico College of Pharmacy.
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Triple-isotope imaging of a rat

University of New Mexico | Rat, Dual-Isotope, Ga-67, Tc-99m, Tl-201, Animation

		Comments
		SPECT/CT imaging was performed on a rat following administration of three isotopes. 1.1mCi (41MBq) of Tc^99m-MDP, 560uCi (21MBq) of Ga⁶⁷, and 1.05mCi (39MBq) of Tl²⁰¹-Chloride were injected into a rat. A 60-minute acquisitions was acquired at 60-minutes post-injection. On the left are displayed the results of the Tc^99m (gray) and Tl²⁰¹ (purple) reconstructions to highlight the clear Tl²⁰¹ uptake in the heart and the distribution of the MDP to the bones. The right-hand side of the image also includes the Ga⁶⁷ (green) distribution which was more diffuse throughout the entirety of the body. Images courtesy of The University of New Mexico, College of Pharmacy.
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Triple-isotope imaging of a mouse

University of New Mexico | Mouse, SPECT/CT, Dual-Isotope, Tc-99m, I-123, Tl-201

		Comments
		SPECT/CT imaging of a mouse was performed following administration of three isotopes. 700uCi (26MBq) of Tc^99m-MDP, 1.2mCi (44MBq) of I¹²³, and 300uCi (11MBq) of Tl²⁰¹ were injected. Imaging was performed for 56 minutes at 60 minutes post-injection. MDP bone uptake is visualized in gray, I¹²³ uptake (red) is clearly visible in the thyroid, small intestine, and eyes, while Tl²⁰¹ (green) uptake is mostly evident in the kidneys. Images courtesy of The University of New Mexico College of Pharmacy.
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Demonstration of crosstalk correction between Tc-99m and I-123

University of New Mexico | Rat, SPECT/CT, Dual-Isotope, Tc-99m, I-123

		Comments
		Dual-isotope SPECT/CT imaging was performed on a rat following administration of Tc^99m-MDP (450uCi, 17MBq) and I¹²³ (1.4mCi, 52MBq). Image data were acquired for 60 minutes at 60 minutes post-injection. The image displays two reconstructions of the Tc^99m SPECT projection data. In the left-hand image, no corrections have been included to account for crosstalk of down-scattered I¹²³ photons into the Tc<up>99m energy window. Therefore, uptake in the thyroid and small intestine is clearly visible. In the right-hand image, a crosstalk correction method has been applied. The evidence of the I¹²³ distribution is eliminated without degradation of the reconstruction of the Tc^99m distribution. Images courtesy of The University of New Mexico, College of Pharmacy.
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High-resolution CT imaging of microcalcification of breast cancer

Frangioni Lab./Longwood SAIF | Mouse, CT only

		Comments
		Displayed is high-resolution ex vivo image of microcalcification of breast cancer. A CT scan was performed with tube voltage of 45 kVp, 177µA current, 3000 ms/projection, 360 projections/rotation. The pixel size of detector was set to 96 µm. This image was acquired in 18 minutes. Exact cone beam algorithm with a Shepp-Logan filter and 10-micron voxel size was used for reconstruction (using InVivoScope post-processing software). The image is courtesy the Frangioni Laboratory, Longwood SAIF, Harvard Medical school.
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Re-188 labeled oligomer (mouse, MIP)

UMass Medical School | Mouse, SPECT/CT, Re-188

		Comments
		Pretargeting has been attracting increasing attention as a drug delivery approach. We recently proposed Watson-Crick pairing of phosphorodiamidate morpholino oligomers (MORF) for the recognition system in tumor pretargeting. MORF pretargeting involves the initial i.v. injection of a MORF-conjugated antitumor antibody and the subsequent i.v. injection of the radiolabeled complement. Our laboratory has reported on MORF pretargeting for diagnosis using 99mTc as radiolabel. We now report on the use of MORF pretargeting for radiotherapy in a mouse tumor model using 188Re as the therapeutic radiolabel. For more details see: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1587615
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