HOME CONTACT OUR PARTNERS         SELECT STUDIES All Mouse Rat Other Species Object SPECT only CT only SPECT/CT Enhanced CT PET MRI Dual-Isotope Dynamic/Gated Ga-67 Tc-99m I-123 I-125 I-131 Lu-177 In-111 Re-188 Tl-201 Animation Simulation Segmentation STOP MOVIES UPLOAD YOUR STUDY APPLICATION NOTES TRACER DATABASE inviCRO 4th Bioscan User Meeting:

You are logged in as: AN65331   SPECT-CT imaging of small peritoneal carcinomatosis. IRCMontpellier | Mouse, SPECT/CT, I-125 edit download original mpeg We previously assessed the efficiency of intravenous injections of 125I-labeled mAbs for the treatment of small peritoneal carcinomatosis (Santoro et al, J. Nucl Med 2009). In the present study, athymic nude mice bearing intraperitoneal A-431 tumor cell xenografts expressing CEA receptors were intraperitoneally injected with 125I-35A7 mAb at days 4 following tumor cells xenograft. SPECT-CT imaging shows strong uptake of 125I-mAbs by tumors nodules, and demonstrates its usefulness for radioimmunotherapy of small solid tumors. Tracer details : The non-internalizing murine IgG1k 35A7 mAb, specific for the CEA Gold 2 epitope, was used to target CEA in transfected A-431 cells. Radiolabeling with iodine 125 was done according to the IODO-GEN method. Contributor : Jean-Pierre Pouget, IRCM See also: