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Show NanoSPECT studies: Animation

[13 hits] | Set 1| Set 2

Quintuple Image Co-Registration

		Comments
		A quadruple isotope SPECT/CT imaging acquisition was performed on a rat. 450uCi (17MBq) of Tc^99m-MDP, 1.4mCi (52MBq) of I¹²³, 600uCi (22MBq) of In¹¹¹, and 1mCi (37MBq) of Tl²⁰¹-Chloride were administered to the rat. A 40-minute image acquisition was performed at 3 hours post-injection of the Tc^99m/I¹²³ and 1 hour post-injection of the In¹¹¹/Tl²⁰¹. The color bars from left to right are: CT, Tc^99m, I¹²³, In¹¹¹ and Tl²⁰¹. Please see [158] for more details. Data courtesy of the University of New Mexico College of Pharmacy.
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Dual-Isotope ECG-Gated SPECT/CT of a Rat

		Comments
		Dual-isotope ECG-gated SPECT/CT imaging was performed on a rat. 800uCi (30MBq) of Tc^99m-SestaMIBI and 970uCi (36MBq) of Tl²⁰¹-Chloride were injected into a rat. Data were acquired for 45 minutes at 60 minutes post-injection. Average heart rate was stable at ~320 BPM with the rat held under gas anesthesia. The image presents Tc^99m+CT data on the left and Tl²⁰¹+CT data on the right. Images courtesy of the University of New Mexico. [Tracer Details]
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Triple-isotope imaging of a rat

		Comments
		SPECT/CT imaging was performed on a rat following administration of three isotopes. 1.1mCi (41MBq) of Tc^99m-MDP, 560uCi (21MBq) of Ga⁶⁷, and 1.05mCi (39MBq) of Tl²⁰¹-Chloride were injected into a rat. A 60-minute acquisitions was acquired at 60-minutes post-injection. On the left are displayed the results of the Tc^99m (gray) and Tl²⁰¹ (purple) reconstructions to highlight the clear Tl²⁰¹ uptake in the heart and the distribution of the MDP to the bones. The right-hand side of the image also includes the Ga⁶⁷ (green) distribution which was more diffuse throughout the entirety of the body. Images courtesy of The University of New Mexico, College of Pharmacy.
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inviCRO Onion Model: Oncology

		Comments
		The results of an automated tumor segmentation of a mouse using inviCRO's digital scalpel powered by Definiens. The layered model or "onion" model is generated via topographical thinning or "peeling" of the segmented tumor. The four scenes are comprised of (left-to-right) an X-Ray CT (used to segment the tumor), the CT plus related SPECT data of the entire animal, the CT plus SPECT of the segmented tumor only (different color scale), and the CT plus inviCRO's onion model of the segmented tumor. This model, applicable to various imaging fields (see [148]), allows to analyze uptake within an organ. Special thanks to Ben Gershman, University of New Mexico and Dr. Jacob Hesterman, Bioscan for their support.
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CT-based brain segmentation in a mouse (slices)

		Comments
		Exemplary segmentation of a mouse brain using the CT component of a NanoSPECT/CT image only. On the left hand side, the original CT slices are shown, while the right images displays a fusion with the four different classifications of this image (background=gray, body=red, bone=white, brain=yellow). Such classified anatomical data can subsequently be used to isolate organs from other modalities and thus achieve very precise and reliable information on, for instance, uptake. See [141] for further details. InviCRO offers tools for automated segmentation for this and many other applications.
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Automatic Biodistribution from inviCRO (Rendering powered by Definiens)

		Comments
		Displayed: Image rendering of an automated 3D segmentation of a dual-modality study from the NanoSPECT/CT (Tc99m-Glucarate on a tumor bearing mouse; early stage) using the Definiens Developer XD software platform. The relevant color-coded organs shown in the animation were segmented and classified using a step-wise Rule Set specific to 3D SPECT-CT image acquisitions. The above movie was generated as a collaborative effort between Definiens, inviCRO and Bioscan.
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Automatic Biodistribution from inviCRO (powered by Definiens)

		Comments
		Displayed: On the left-hand side is a standard maximum intensity projection (MIP) of a study performed on a NanoSPECT/CT of Tc99m-Glucarate in a mouse with a very early stage tumor. The image on the right-hand side is also a MIP, however instead of a standard SPECT image the data set co-registered with the CT was generated by assigning integer values to organs automatically segmented using the Definiens Developer XD software platform. The data set was classified using a step-wise Rule Set specific to 3D SPECT-CT image acquisitions. The above movie was generated as a collaborative effort between Definiens, inviCRO and Bioscan.
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Quintuple Image Co-Registration (Checkerboard)

		Comments
		A quadruple isotope SPECT/CT imaging acquisition was performed on a rat. 450uCi (17MBq) of Tc^99m-MDP, 1.4mCi (52MBq) of I¹²³, 600uCi (22MBq) of In¹¹¹, and 1mCi (37MBq) of Tl²⁰¹-Chloride were administered to the rat. A 40-minute image acquisition was performed at 3 hours post-injection of the Tc^99m/I¹²³ and 1 hour post-injection of the In¹¹¹/Tl²⁰¹. The color bars from left to right are: CT, Tc^99m, I¹²³, In¹¹¹ and Tl²⁰¹. Please see [158] for more details. Data courtesy of the University of New Mexico College of Pharmacy.
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Automatic Biodistribution from inviCRO (Classifications, powered by Definiens)

		Comments
		The animation shows the classification of a SPECT/CT scan in which the visibility of classes is switched on and off in a circle. Please see [135] for further details.
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Mouse Fullbody CT (helical reconstruction)

		Comments
		Visualization of helical CT reconstruction in seesaw mode.
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