Dual-isotope ECG-gated SPECT/CT imaging was performed on a rat. 800uCi (30MBq) of Tc99m-SestaMIBI and 970uCi (36MBq) of Tl201-Chloride were injected into a rat. Data were acquired for 45 minutes at 60 minutes post-injection. Average heart rate was stable at ~320 BPM with the rat held under gas anesthesia. The image presents Tc99m+CT data on the left and Tl201+CT data on the right.
A quadruple isotope SPECT/CT imaging acquisition was performed on a rat. 450uCi (17MBq) of Tc99m-MDP, 1.4mCi (52MBq) of I123, 600uCi (22MBq) of In111, and 1mCi (37MBq) of Tl201-Chloride were administered to the rat. A 40-minute image acquisition was performed at 3 hours post-injection of the Tc99m/I123 and 1 hour post-injection of the In111/Tl201. From left to right, the image displays reconstructions of Tc99m (gray; bone uptake), I123 (purple; thyroid and small intestine uptake), In111 (blue; heart, liver, and intestine uptake), and Tl201 (red; kidney, liver, and heart uptake).
Images courtesy of the University of New Mexico College of Pharmacy.
SPECT/CT imaging was performed on a rat following administration of three isotopes. 1.1mCi (41MBq) of Tc99m-MDP, 560uCi (21MBq) of Ga67, and 1.05mCi (39MBq) of Tl201-Chloride were injected into a rat. A 60-minute acquisitions was acquired at 60-minutes post-injection. On the left are displayed the results of the Tc99m (gray) and Tl201 (purple) reconstructions to highlight the clear Tl201 uptake in the heart and the distribution of the MDP to the bones. The right-hand side of the image also includes the Ga67 (green) distribution which was more diffuse throughout the entirety of the body.
Images courtesy of The University of New Mexico, College of Pharmacy.
SPECT/CT imaging of a mouse was performed following administration of three isotopes. 700uCi (26MBq) of Tc99m-MDP, 1.2mCi (44MBq) of I123, and 300uCi (11MBq) of Tl201 were injected. Imaging was performed for 56 minutes at 60 minutes post-injection. MDP bone uptake is visualized in gray, I123 uptake (red) is clearly visible in the thyroid, small intestine, and eyes, while Tl201 (green) uptake is mostly evident in the kidneys.
Images courtesy of The University of New Mexico College of Pharmacy.
Dual-isotope SPECT/CT imaging was performed on a rat following administration of Tc99m-MDP (450uCi, 17MBq) and I123 (1.4mCi, 52MBq). Image data were acquired for 60 minutes at 60 minutes post-injection. The image displays two reconstructions of the Tc99m SPECT projection data. In the left-hand image, no corrections have been included to account for crosstalk of down-scattered I123 photons into the Tc<up>99m energy window. Therefore, uptake in the thyroid and small intestine is clearly visible. In the right-hand image, a crosstalk correction method has been applied. The evidence of the I123 distribution is eliminated without degradation of the reconstruction of the Tc99m distribution.
Images courtesy of The University of New Mexico, College of Pharmacy.
As published by the Molecular Imaging Center for Excellence newsletter, SNM publication Volume 2, 2008-1:
Maximum Intensity Projection (MIP) of a dual-isotope (Tc-99m and I-123) SPECT/CT mouse study. All combinations of fusions of CT with Tc-99m- and I-123-SPECT are shown here.
Please note in particular, that the energy resolution of the NanoSPECT is good enough to resolve Tc-99m (140.5 keV) and I-123 (159.0 keV) while still providing the high sensitivity.
High resolution mouse cardiac study usuing Tc-99m labeled MIBI. Additionally, the mouse was injected straight I-123 showing up in the thyroids. All combinations of fusions of CT with Tc-99m- and I-123- SPECT are shown here.
Marked with a cross is the mouse heart.
Please note in particular, that the energy resolution of the NanoSPECT is good enough to resolve Tc-99m (140.5 keV) and I-123 (159.0 keV) while still providing the high sensitivity.
