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Show NanoSPECT studies: Dynamic/Gated

[14 hits] | Set 1| Set 2

Dual-Isotope ECG-Gated SPECT/CT of a Rat

		Comments
		Dual-isotope ECG-gated SPECT/CT imaging was performed on a rat. 800uCi (30MBq) of Tc^99m-SestaMIBI and 970uCi (36MBq) of Tl²⁰¹-Chloride were injected into a rat. Data were acquired for 45 minutes at 60 minutes post-injection. Average heart rate was stable at ~320 BPM with the rat held under gas anesthesia. The image presents Tc^99m+CT data on the left and Tl²⁰¹+CT data on the right. Images courtesy of the University of New Mexico. [Tracer Details]
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Cardiac Gating with Human Serum Albumin (HSA)

		Comments
		A mouse was injected via tail vein with ~35 MBq (< 1mCi) of Tc-labeled human serum albumin (HSA). Imaging began immediately (~2 minutes) post-injection. Two acquisitions (one 16-minutes and one 32-minutes) were performed in succession. Projection data from the two acquisitions were combined (via the IVS Sum Projections tool). Eight frames were used for the gating. Mouse cardiac rate was stable and between 250-300 BPM for the duration of the acquisition. Images courtesy of Dr. Fijs van Leeuwen at the National Cancer Institute, Amsterdam, Netherlands (NKI-AVL)
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Respiratory Gating with macro aggregate albumin (MAA)

		Comments
		Bioscan's Featured Study of the 4th Quarter: A mouse was injected with ~19MBq (~0.5mCi) of Tc99m-labeled macro-aggregated albumin (MAA). Imaging was performed 60 minutes post-injection. Respiratory gating was performed using an external box from SA Instruments. A small pneumatic pillow is used to detect respiration Data were acquired over 12 minutes, using 6 frames. Respiratory rates were stable and around 130 BPM throughout the acquisition. Images courtesy of Dr. Fijs van Leeuwen at the National Cancer Institute, Amsterdam, Netherlands (NKI-AVL).
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Cardiac-gated mouse heart

		Comments
		A scout CT scan was collected to pinpoint the heart and liver location in a mouse (maximizing efficiency) injected with Tc^99m-labeled MIBI. The animal was anesthetized with sodium pentobarbitol (Nembutol). Focused cardiac-gated (ECG) heart/liver data were acquired with 24 projections collected over an 18mm scan range using 4 apertures equipped with 9 pinholes of 1.4mm diameter (allowing a resolution down to 1.1 mm). Count rates (heart and liver) were approximately 2500 cps. The heart rate was >200 bpm with the cardiac cycle divided into 8 frames. Special thanks to Dr. Jacob Hesterman for imaging and post-processing, and Dr. Domokos Mathe for the animal handling. [Tracer Details]
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I-131 Mouse Tumor Study (Longitudinal: 19h, 168h, 456h p.i.)

		Comments
		Longitudinal tumor study in a mouse using I¹³¹ (8d phys. half life, 364 keV peak) labeled I¹³¹-CLR1404 (a radioiodinated phospholipid ether analog), imaged 19 hours (left) and 7 days (middle) and 19 days (right) post injection. At times of acquisition, the mouse contained as little as 11 MBq (300 µCi) of I¹³¹. However, even weeks later, the uptake in the tumor is still clearly detectable, thus allowing for longitudinal studies, tracking the development of tumors in individual animals. Despite the high energy of the I¹³¹ photons and the low activity, there is a strong signal of the tumor visible in all images. In the right image, a post-processing smoothing filter was applied (Gauss, 2 mm FWHM). For more details on the tracer see: http://cellectar.com/sciences/ Imaged at the UNM for Cellectar, LLC
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Respiratory Gated Mouse (All views)

		Comments
		Respiratory gated scan of the torso of a mouse, showing liver, gallbladder and kidneys. Visible are a (M)aximum Intensity Projection, (C)oronal, (S)agittal and (T)ransversal views. Imaging parameters: 2mCi of Tc^99m-labeled MIBI imaged 45 minutes post injection in a 32 minute acquisition. Special thanks to Ben Gershman and Jacob Hesterman for image acquisition and post-processing. [Tracer Details]
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Tc-99m Myoview Gated Rat Heart

		Comments
		A rat was injected with ~75 MBq (2 mCi) of Tc-labeled Myoview and imaged 30 minutes post-injection for 1 hour. The rat was anesthetized using Isofluorane and exhibited a stable heart rate of ~250 BPM. Rejection rate was near zero and only a slight decrease in heart rate was observed (and adjusted for) over the course of the acquisition. Image courtesy of the University of Ottawa Heart Institute. [Tracer Details]
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Dynamic Mouse Tumor (In-111, movie)

		Comments
		Bioscan's Image of the Month May: A nude mouse with a pancreatic tumor on its right shoulder. Injected with an 30 MBq (0.8 mCi) of In-111 labeled monomer. Scan range - 35.4mm (just the heart and the tumor were scanned). In total 24 scans, just below 5 minutes each, where performed, summing up to a 2 hour acquisition time. By courtesy of Ciara Finucane (aka SU1). Centre for Cancer Imaging, Barts and The London Queen Mary's School of Medicine and Dentistry London
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Respiratory cycle CT scan (mouse)

		Comments
		CT scan of a mouse illustrating respiratory cycle. No additional hardware required.
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Dynamic Tumor Study (In-111 Dotatate, Mouse)

		Comments
		Dynamic tumor study in mouse. 1.9 mCi of Indium-111-Dotatate injected. Measured 29 scans of 2 minutes each using the high sensitivity mouse aperture (APT1, 9-pinholes, 1.4 mm diameter) on a scan range of 35 mm. 16 projections per cycle, 2 cycles per study. Total scan time was 1 hour. Please note, the animal moved slightly at end of measurement.
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