A quadruple isotope SPECT/CT imaging acquisition was performed on a rat. 450uCi (17MBq) of Tc99m-MDP, 1.4mCi (52MBq) of I123, 600uCi (22MBq) of In111, and 1mCi (37MBq) of Tl201-Chloride were administered to the rat. A 40-minute image acquisition was performed at 3 hours post-injection of the Tc99m/I123 and 1 hour post-injection of the In111/Tl201.
The color bars from left to right are: CT, Tc99m, I123, In111 and Tl201.
A cohort of ferrets was induced with the flu in an attempt to visualize uptake of radiotracer in the sinuses. In this trial experiment 590uCi of In-111 (green) labeled with an inflammation targeting agent were injected. A fast, 7-minute CT acquisition was acquired over a 230mm scan range followed by a 20-minute SPECT acquisition. In-111 uptake in the trachea, heart, and lymphatic regions is clearly visible. Note also the striations visible in the ferret's trachea.
Images courtesy of the University of New Mexico, College of Pharmacy, and the Lovelace Respiratory Research Institute.
A quadruple isotope SPECT/CT imaging acquisition was performed on a rat. 450uCi (17MBq) of Tc99m-MDP, 1.4mCi (52MBq) of I123, 600uCi (22MBq) of In111, and 1mCi (37MBq) of Tl201-Chloride were administered to the rat. A 40-minute image acquisition was performed at 3 hours post-injection of the Tc99m/I123 and 1 hour post-injection of the In111/Tl201. From left to right, the image displays reconstructions of Tc99m (gray; bone uptake), I123 (purple; thyroid and small intestine uptake), In111 (blue; heart, liver, and intestine uptake), and Tl201 (red; kidney, liver, and heart uptake).
Images courtesy of the University of New Mexico College of Pharmacy.
Bioscan's Image of the Month May: A nude mouse with a pancreatic tumor on its right shoulder. Injected with an 30 MBq (0.8 mCi) of In-111 labeled monomer. Scan range - 35.4mm (just the heart and the tumor were scanned). In total 24 scans, just below 5 minutes each, where performed, summing up to a 2 hour acquisition time.
By courtesy of Ciara Finucane (aka SU1). Centre for Cancer Imaging, Barts and The London Queen Mary's School of Medicine and Dentistry London
2.6 mCi of In-111 Dotatoc was injected into a 1.5 kg, male rabbit. An 18-minute acquisition was started 5 minutes post injection using an LEUHR collimator on a NanoSPECT/CT. Reconstructions were performed with the Scivis ReSPECT parallel-hole reconstruction software.
Dynamic tumor study in mouse. 1.9 mCi of Indium-111-Dotatate injected. Measured 29 scans of 2 minutes each using the high sensitivity mouse aperture (APT1, 9-pinholes, 1.4 mm diameter) on a scan range of 35 mm. 16 projections per cycle, 2 cycles per study. Total scan time was 1 hour.
Please note, the animal moved slightly at end of measurement.
Mouse with tumor injected with 10MBq of In-111 attached to tracer under development. The mouse was imaged 4 hours post-injection. A gamma- counter was used to estimate the uptake in the tumor (post-mortem) and it was estimated to contain approximately 0.3MBq of In-111.
SPECT/CT study of a 390g rat, injected with 0.9 mCi of In-111 labeled Octreoscan. The study was performed 3 hours post injection and took 16 minutes for a scan range of 100 mm
A quadruple isotope SPECT/CT imaging acquisition was performed on a rat. 450uCi (17MBq) of Tc99m-MDP, 1.4mCi (52MBq) of I123, 600uCi (22MBq) of In111, and 1mCi (37MBq) of Tl201-Chloride were administered to the rat. A 40-minute image acquisition was performed at 3 hours post-injection of the Tc99m/I123 and 1 hour post-injection of the In111/Tl201.
The color bars from left to right are: CT, Tc99m, I123, In111 and Tl201.