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Show NanoSPECT studies: Rat

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Quintuple Image Co-Registration

inviCRO, Boston | Rat, SPECT/CT, Tc-99m, I-123, In-111, Tl-201, Animation

		Comments
		A quadruple isotope SPECT/CT imaging acquisition was performed on a rat. 450uCi (17MBq) of Tc^99m-MDP, 1.4mCi (52MBq) of I¹²³, 600uCi (22MBq) of In¹¹¹, and 1mCi (37MBq) of Tl²⁰¹-Chloride were administered to the rat. A 40-minute image acquisition was performed at 3 hours post-injection of the Tc^99m/I¹²³ and 1 hour post-injection of the In¹¹¹/Tl²⁰¹. The color bars from left to right are: CT, Tc^99m, I¹²³, In¹¹¹ and Tl²⁰¹. Please see [158] for more details. Data courtesy of the University of New Mexico College of Pharmacy.
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Dual-Isotope ECG-Gated SPECT/CT of a Rat

University of New Mexico | Rat, SPECT/CT, Dual-Isotope, Dynamic/Gated, Tc-99m, Tl-201, Animation

		Comments
		Dual-isotope ECG-gated SPECT/CT imaging was performed on a rat. 800uCi (30MBq) of Tc^99m-SestaMIBI and 970uCi (36MBq) of Tl²⁰¹-Chloride were injected into a rat. Data were acquired for 45 minutes at 60 minutes post-injection. Average heart rate was stable at ~320 BPM with the rat held under gas anesthesia. The image presents Tc^99m+CT data on the left and Tl²⁰¹+CT data on the right. Images courtesy of the University of New Mexico. [Tracer Details]
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Quadruple-isotope imaging in a rat

University of New Mexico | Rat, SPECT only, Dual-Isotope, Tc-99m, I-123, In-111, Tl-201

		Comments
		A quadruple isotope SPECT/CT imaging acquisition was performed on a rat. 450uCi (17MBq) of Tc^99m-MDP, 1.4mCi (52MBq) of I¹²³, 600uCi (22MBq) of In¹¹¹, and 1mCi (37MBq) of Tl²⁰¹-Chloride were administered to the rat. A 40-minute image acquisition was performed at 3 hours post-injection of the Tc^99m/I¹²³ and 1 hour post-injection of the In¹¹¹/Tl²⁰¹. From left to right, the image displays reconstructions of Tc^99m (gray; bone uptake), I¹²³ (purple; thyroid and small intestine uptake), In¹¹¹ (blue; heart, liver, and intestine uptake), and Tl²⁰¹ (red; kidney, liver, and heart uptake). Images courtesy of the University of New Mexico College of Pharmacy.
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Triple-isotope imaging of a rat

University of New Mexico | Rat, Dual-Isotope, Ga-67, Tc-99m, Tl-201, Animation

		Comments
		SPECT/CT imaging was performed on a rat following administration of three isotopes. 1.1mCi (41MBq) of Tc^99m-MDP, 560uCi (21MBq) of Ga⁶⁷, and 1.05mCi (39MBq) of Tl²⁰¹-Chloride were injected into a rat. A 60-minute acquisitions was acquired at 60-minutes post-injection. On the left are displayed the results of the Tc^99m (gray) and Tl²⁰¹ (purple) reconstructions to highlight the clear Tl²⁰¹ uptake in the heart and the distribution of the MDP to the bones. The right-hand side of the image also includes the Ga⁶⁷ (green) distribution which was more diffuse throughout the entirety of the body. Images courtesy of The University of New Mexico, College of Pharmacy.
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Demonstration of crosstalk correction between Tc-99m and I-123

University of New Mexico | Rat, SPECT/CT, Dual-Isotope, Tc-99m, I-123

		Comments
		Dual-isotope SPECT/CT imaging was performed on a rat following administration of Tc^99m-MDP (450uCi, 17MBq) and I¹²³ (1.4mCi, 52MBq). Image data were acquired for 60 minutes at 60 minutes post-injection. The image displays two reconstructions of the Tc^99m SPECT projection data. In the left-hand image, no corrections have been included to account for crosstalk of down-scattered I¹²³ photons into the Tc<up>99m energy window. Therefore, uptake in the thyroid and small intestine is clearly visible. In the right-hand image, a crosstalk correction method has been applied. The evidence of the I¹²³ distribution is eliminated without degradation of the reconstruction of the Tc^99m distribution. Images courtesy of The University of New Mexico, College of Pharmacy.
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inviCRO Onion Model: Respiratory analysis

inviCRO, Boston | Rat, SPECT/CT, Tc-99m, Segmentation

		Comments
		A three-part animation displaying the results of an automated lung segmentation of a rat using the newly developed inviCRO digital scalpel powered by Definiens. The layered model or "onion" model of the lung is then generated via topographical thinning or "peeling" of the segmented lung. Application of this model to the image data allows for automated, quantifiable deposition of the relevant radiopharmaceutical in the lung. The three scenes are comprised of an X-Ray CT/Onion model fusion, SPECT/CT and lastly SPECT/Onion model.
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Inhalant aerosol imaging in a rat (automatic segmenation of lungs)

inviCRO, Boston | Rat, CT only, Segmentation

		Comments
		To analyze the aerosol images shown in [131] and [133], inviCRO developed a segmentation rule set for Definiens' Developer XD software. This does not only allow for very precise and consistent segmentation of a single image, but can easily be used for batch-processing of an array of images. The CT-only based segmentation delivers valuable anatomical information to analyze the information gained from the SPECT scans. To isolate the lungs from the rest of the image, inviCRO used their digital scalpel. Special thanks to Ky Harlin (inviCRO, LLC) for the image processing. For additional details on the mouse data, please see above links.
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Tri-modality rat brain data: Application of CT brain segmentation

inviCRO, Boston | Rat, SPECT/CT, MRI, I-125, Segmentation

		Comments
		A tri-modality (grayscale MRI, green SPECT, NIH Fire2 CT) MIP of a rat brain acquired by inviCRO at the Center for Translational Neuroimaging in the newly created imaging facility at Northeastern University. A rule set (written in the Definiens Developer package) was applied to the CT data to automatically segment the brain and bones. The resulting segmentation was used in inviCRO's digital scalpel to isolate brain from the MR and SPECT data with anatomical reference supplied by the bone CT data. The MRI (100umx100umx500um, 30min acq.) was acquired on a 7T Bruker magnet using a spin-echo sequence (RARE) comprised of 50 slices with 6 averages. The SPECT (600um voxels, 30min acq.) and CT (400um voxels, 4.5min acq.) images were generated on a NanoSPECT/CT. 400 uCi of I125-beta-CIT (a dopamine and serotonin transporter imaging agent) was injected 4.5 hours prior to the SPECT study. After this process, the image data is now ready for futher analysis, such as estimating uptake in different regions of the brain. The unsegmented data can be found in [139] and [138]. Special thanks to Dr. Hesterman (Bioscan) for the data processing. [Tracer Details]
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Tri-modality rat brain data: Transverse slices of brain segmentation

inviCRO, Boston | Rat, SPECT/CT, MRI, I-125, Segmentation

		Comments
		The transverse slices of rat brain data with MRI (grayscale), CT (NIH Fire 2), and SPECT (green) acquired by inviCRO at the Center for Translational Neuroimaging in the newly created imaging facility at Northeastern University (using a 7R Bruker magnet and Bioscan's NanoSPECT/CT). Please see entry [141] for further details. The unsegmented data can be found in [139] and [138]. [Tracer Details]
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Triple Modality Rat Study (MR, SPECT, CT; slices)

inviCRO, Boston | Rat, SPECT/CT, MRI, I-125

		Comments
		Transverse slices from a tri-modality study (MRI, SPECT, CT) of a rat brain acquired at the Center for Translational Neuroimaging in the newly created imaging facility at Northeastern University. The MRI (grayscale, 100umx100umx500um, 30min acq.) was acquired on a 7T Bruker magnet using a spin-echo sequence (RARE) comprised of 50 slices with 6 averages. The SPECT (green, 600um voxels, 30min acq.) and CT (NIH Fire2, 400um voxels, 4.5min acq.) images were generated on a NanoSPECT/CT. 400 uCi of I125-beta-CIT (a dopamine and serotonin transporter imaging agent) was injected 4.5 hours prior to the SPECT study. Tracer localized in eyes, striatum and thyroid. Animal was imaged on a Minerve bed under isoflurane. Data registration and presentation supported by inviCRO. [Tracer Details]
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