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Show NanoSPECT studies: Tc-99m

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Quintuple Image Co-Registration

inviCRO, Boston | Rat, SPECT/CT, Tc-99m, I-123, In-111, Tl-201, Animation

		Comments
		A quadruple isotope SPECT/CT imaging acquisition was performed on a rat. 450uCi (17MBq) of Tc^99m-MDP, 1.4mCi (52MBq) of I¹²³, 600uCi (22MBq) of In¹¹¹, and 1mCi (37MBq) of Tl²⁰¹-Chloride were administered to the rat. A 40-minute image acquisition was performed at 3 hours post-injection of the Tc^99m/I¹²³ and 1 hour post-injection of the In¹¹¹/Tl²⁰¹. The color bars from left to right are: CT, Tc^99m, I¹²³, In¹¹¹ and Tl²⁰¹. Please see [158] for more details. Data courtesy of the University of New Mexico College of Pharmacy.
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Dual-Isotope ECG-Gated SPECT/CT of a Rat

University of New Mexico | Rat, SPECT/CT, Dual-Isotope, Dynamic/Gated, Tc-99m, Tl-201, Animation

		Comments
		Dual-isotope ECG-gated SPECT/CT imaging was performed on a rat. 800uCi (30MBq) of Tc^99m-SestaMIBI and 970uCi (36MBq) of Tl²⁰¹-Chloride were injected into a rat. Data were acquired for 45 minutes at 60 minutes post-injection. Average heart rate was stable at ~320 BPM with the rat held under gas anesthesia. The image presents Tc^99m+CT data on the left and Tl²⁰¹+CT data on the right. Images courtesy of the University of New Mexico. [Tracer Details]
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Quadruple-isotope imaging in a rat

University of New Mexico | Rat, SPECT only, Dual-Isotope, Tc-99m, I-123, In-111, Tl-201

		Comments
		A quadruple isotope SPECT/CT imaging acquisition was performed on a rat. 450uCi (17MBq) of Tc^99m-MDP, 1.4mCi (52MBq) of I¹²³, 600uCi (22MBq) of In¹¹¹, and 1mCi (37MBq) of Tl²⁰¹-Chloride were administered to the rat. A 40-minute image acquisition was performed at 3 hours post-injection of the Tc^99m/I¹²³ and 1 hour post-injection of the In¹¹¹/Tl²⁰¹. From left to right, the image displays reconstructions of Tc^99m (gray; bone uptake), I¹²³ (purple; thyroid and small intestine uptake), In¹¹¹ (blue; heart, liver, and intestine uptake), and Tl²⁰¹ (red; kidney, liver, and heart uptake). Images courtesy of the University of New Mexico College of Pharmacy.
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Triple-isotope imaging of a rat

University of New Mexico | Rat, Dual-Isotope, Ga-67, Tc-99m, Tl-201, Animation

		Comments
		SPECT/CT imaging was performed on a rat following administration of three isotopes. 1.1mCi (41MBq) of Tc^99m-MDP, 560uCi (21MBq) of Ga⁶⁷, and 1.05mCi (39MBq) of Tl²⁰¹-Chloride were injected into a rat. A 60-minute acquisitions was acquired at 60-minutes post-injection. On the left are displayed the results of the Tc^99m (gray) and Tl²⁰¹ (purple) reconstructions to highlight the clear Tl²⁰¹ uptake in the heart and the distribution of the MDP to the bones. The right-hand side of the image also includes the Ga⁶⁷ (green) distribution which was more diffuse throughout the entirety of the body. Images courtesy of The University of New Mexico, College of Pharmacy.
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Triple-isotope imaging of a mouse

University of New Mexico | Mouse, SPECT/CT, Dual-Isotope, Tc-99m, I-123, Tl-201

		Comments
		SPECT/CT imaging of a mouse was performed following administration of three isotopes. 700uCi (26MBq) of Tc^99m-MDP, 1.2mCi (44MBq) of I¹²³, and 300uCi (11MBq) of Tl²⁰¹ were injected. Imaging was performed for 56 minutes at 60 minutes post-injection. MDP bone uptake is visualized in gray, I¹²³ uptake (red) is clearly visible in the thyroid, small intestine, and eyes, while Tl²⁰¹ (green) uptake is mostly evident in the kidneys. Images courtesy of The University of New Mexico College of Pharmacy.
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Demonstration of crosstalk correction between Tc-99m and I-123

University of New Mexico | Rat, SPECT/CT, Dual-Isotope, Tc-99m, I-123

		Comments
		Dual-isotope SPECT/CT imaging was performed on a rat following administration of Tc^99m-MDP (450uCi, 17MBq) and I¹²³ (1.4mCi, 52MBq). Image data were acquired for 60 minutes at 60 minutes post-injection. The image displays two reconstructions of the Tc^99m SPECT projection data. In the left-hand image, no corrections have been included to account for crosstalk of down-scattered I¹²³ photons into the Tc<up>99m energy window. Therefore, uptake in the thyroid and small intestine is clearly visible. In the right-hand image, a crosstalk correction method has been applied. The evidence of the I¹²³ distribution is eliminated without degradation of the reconstruction of the Tc^99m distribution. Images courtesy of The University of New Mexico, College of Pharmacy.
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inviCRO Onion Model: Oncology

University of New Mexico | Mouse, SPECT/CT, Tc-99m, Animation, Segmentation

		Comments
		The results of an automated tumor segmentation of a mouse using inviCRO's digital scalpel powered by Definiens. The layered model or "onion" model is generated via topographical thinning or "peeling" of the segmented tumor. The four scenes are comprised of (left-to-right) an X-Ray CT (used to segment the tumor), the CT plus related SPECT data of the entire animal, the CT plus SPECT of the segmented tumor only (different color scale), and the CT plus inviCRO's onion model of the segmented tumor. This model, applicable to various imaging fields (see [148]), allows to analyze uptake within an organ. Special thanks to Ben Gershman, University of New Mexico and Dr. Jacob Hesterman, Bioscan for their support.
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inviCRO Onion Model: Respiratory analysis

inviCRO, Boston | Rat, SPECT/CT, Tc-99m, Segmentation

		Comments
		A three-part animation displaying the results of an automated lung segmentation of a rat using the newly developed inviCRO digital scalpel powered by Definiens. The layered model or "onion" model of the lung is then generated via topographical thinning or "peeling" of the segmented lung. Application of this model to the image data allows for automated, quantifiable deposition of the relevant radiopharmaceutical in the lung. The three scenes are comprised of an X-Ray CT/Onion model fusion, SPECT/CT and lastly SPECT/Onion model.
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Aerosol lung deposition in a mouse (Volume rendering)

CNRS, Orleans | Mouse, SPECT/CT, Tc-99m

		Comments
		Approximately 150uCi (in 50uL) of stannous colloids labeled with Tc-99m were nebulized into the lungs of a normal FVB mouse with a microsprayer. Image data were acquired using a high-resolution, whole body multi-pinhole (9) aperture over 18 minutes, beginning approximately 15 minutes post-administration. A fully 3D volume rendering of the SPECT/CT data is shown. Images courtesy of Alain Le Pape, CNRS, Orleans, France
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Automatic Tumor segmentation in Mouse (Volume rendering)

inviCRO, Boston | Mouse, SPECT/CT, Tc-99m, Segmentation

		Comments
		Example of an automated tumor segmentation in a mouse using Definiens' Developer XD software. On the left, a volume rendering of the mouse torso (CT in grayscale, SPECT in NIH Fire 2) is shown, while on the right hand side, the tumor was isolated using inviCRO's digital scalpel tool. The segmentation rule set provided by the Boston-based contract research organization finds the tumor based on its characteristics in the anatomical CT only. This approach not only allows a very precise volume measurement (including necrotic parts of the tumor), but also delivers highly consistent estimates of the tumor uptake from the SPECT image. SPECT and CT images generated on Bioscan's NanoSPECT/CT. Please note, that different SPECT color scales where used in the left and right movie. Special thanks to Dr. Hesterman (Bioscan) for his support in data pre-processing and image generation. The mouse image is courtesy of Ben Gershman (Univ. New Mexico).
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