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Inflammation imaging in ferrets

University of New Mexico | Other Species, SPECT/CT, In-111

		Comments
		A cohort of ferrets was induced with the flu in an attempt to visualize uptake of radiotracer in the sinuses. In this trial experiment 590uCi of In-111 (green) labeled with an inflammation targeting agent were injected. A fast, 7-minute CT acquisition was acquired over a 230mm scan range followed by a 20-minute SPECT acquisition. In-111 uptake in the trachea, heart, and lymphatic regions is clearly visible. Note also the striations visible in the ferret's trachea. Images courtesy of the University of New Mexico, College of Pharmacy, and the Lovelace Respiratory Research Institute.
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Dual-Isotope ECG-Gated SPECT/CT of a Rat

University of New Mexico | Rat, SPECT/CT, Dual-Isotope, Dynamic/Gated, Tc-99m, Tl-201, Animation

		Comments
		Dual-isotope ECG-gated SPECT/CT imaging was performed on a rat. 800uCi (30MBq) of Tc^99m-SestaMIBI and 970uCi (36MBq) of Tl²⁰¹-Chloride were injected into a rat. Data were acquired for 45 minutes at 60 minutes post-injection. Average heart rate was stable at ~320 BPM with the rat held under gas anesthesia. The image presents Tc^99m+CT data on the left and Tl²⁰¹+CT data on the right. Images courtesy of the University of New Mexico. [Tracer Details]
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Quadruple-isotope imaging in a rat

University of New Mexico | Rat, SPECT only, Dual-Isotope, Tc-99m, I-123, In-111, Tl-201

		Comments
		A quadruple isotope SPECT/CT imaging acquisition was performed on a rat. 450uCi (17MBq) of Tc^99m-MDP, 1.4mCi (52MBq) of I¹²³, 600uCi (22MBq) of In¹¹¹, and 1mCi (37MBq) of Tl²⁰¹-Chloride were administered to the rat. A 40-minute image acquisition was performed at 3 hours post-injection of the Tc^99m/I¹²³ and 1 hour post-injection of the In¹¹¹/Tl²⁰¹. From left to right, the image displays reconstructions of Tc^99m (gray; bone uptake), I¹²³ (purple; thyroid and small intestine uptake), In¹¹¹ (blue; heart, liver, and intestine uptake), and Tl²⁰¹ (red; kidney, liver, and heart uptake). Images courtesy of the University of New Mexico College of Pharmacy.
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Triple-isotope imaging of a rat

University of New Mexico | Rat, Dual-Isotope, Ga-67, Tc-99m, Tl-201, Animation

		Comments
		SPECT/CT imaging was performed on a rat following administration of three isotopes. 1.1mCi (41MBq) of Tc^99m-MDP, 560uCi (21MBq) of Ga⁶⁷, and 1.05mCi (39MBq) of Tl²⁰¹-Chloride were injected into a rat. A 60-minute acquisitions was acquired at 60-minutes post-injection. On the left are displayed the results of the Tc^99m (gray) and Tl²⁰¹ (purple) reconstructions to highlight the clear Tl²⁰¹ uptake in the heart and the distribution of the MDP to the bones. The right-hand side of the image also includes the Ga⁶⁷ (green) distribution which was more diffuse throughout the entirety of the body. Images courtesy of The University of New Mexico, College of Pharmacy.
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Triple-isotope imaging of a mouse

University of New Mexico | Mouse, SPECT/CT, Dual-Isotope, Tc-99m, I-123, Tl-201

		Comments
		SPECT/CT imaging of a mouse was performed following administration of three isotopes. 700uCi (26MBq) of Tc^99m-MDP, 1.2mCi (44MBq) of I¹²³, and 300uCi (11MBq) of Tl²⁰¹ were injected. Imaging was performed for 56 minutes at 60 minutes post-injection. MDP bone uptake is visualized in gray, I¹²³ uptake (red) is clearly visible in the thyroid, small intestine, and eyes, while Tl²⁰¹ (green) uptake is mostly evident in the kidneys. Images courtesy of The University of New Mexico College of Pharmacy.
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Demonstration of crosstalk correction between Tc-99m and I-123

University of New Mexico | Rat, SPECT/CT, Dual-Isotope, Tc-99m, I-123

		Comments
		Dual-isotope SPECT/CT imaging was performed on a rat following administration of Tc^99m-MDP (450uCi, 17MBq) and I¹²³ (1.4mCi, 52MBq). Image data were acquired for 60 minutes at 60 minutes post-injection. The image displays two reconstructions of the Tc^99m SPECT projection data. In the left-hand image, no corrections have been included to account for crosstalk of down-scattered I¹²³ photons into the Tc<up>99m energy window. Therefore, uptake in the thyroid and small intestine is clearly visible. In the right-hand image, a crosstalk correction method has been applied. The evidence of the I¹²³ distribution is eliminated without degradation of the reconstruction of the Tc^99m distribution. Images courtesy of The University of New Mexico, College of Pharmacy.
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inviCRO Onion Model: Oncology

University of New Mexico | Mouse, SPECT/CT, Tc-99m, Animation, Segmentation

		Comments
		The results of an automated tumor segmentation of a mouse using inviCRO's digital scalpel powered by Definiens. The layered model or "onion" model is generated via topographical thinning or "peeling" of the segmented tumor. The four scenes are comprised of (left-to-right) an X-Ray CT (used to segment the tumor), the CT plus related SPECT data of the entire animal, the CT plus SPECT of the segmented tumor only (different color scale), and the CT plus inviCRO's onion model of the segmented tumor. This model, applicable to various imaging fields (see [148]), allows to analyze uptake within an organ. Special thanks to Ben Gershman, University of New Mexico and Dr. Jacob Hesterman, Bioscan for their support.
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Inhalant aerosol imaging in a rat (R1)

University of New Mexico | Rat, SPECT/CT, Tc-99m

		Comments
		Specialized equipment was used to administer a colloidal inhalant aerosol to a mouse. Exposure to the aerosol was limited to three minutes, immediately prior to imaging. Estimated dose is ~350uCi (12MBq), although the administration method complicates the dose estimation procedure. Whole-body image data were acquired for 23 minutes (24 projections, 44 seconds per projection), using a standard, whole-body, high-sensitivity aperture. Whole-body CT data were acquired over 10 minutes (180 projections/rotation, 1 second per projection). Images courtesy of Lovelace Respiratory Research Institute and Ben Gershman, University of New Mexico
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Quantitative lung capacity evaluation in a gravid lizard

University of New Mexico | Other Species, CT only, Segmentation

		Comments
		A CT study was performed to quantify the reduction in usable lung capacity in a lizard as a result of gravidity. CT data were acquired late in the gravidity of the lizard and again immediately after the laying of the eggs. Whole-body, six-minute (180 projections/rotation, 1 second per projection) acquisitions were performed in both cases. In the image, the chart displays the quantified change in lung volume (a series of 8-slice, anatomically-based, sub-regions of the lung were used for overall lung volume estimation) as a function of gravidity. The image on the right displays the lung region of the lizard in a gravid state while the imaging the left displays the lung region of the same animal post-gravidity. Images courtesy of Casey Gilman & Ben Gershman, University of New Mexico
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I-131 Mouse Tumor Study (Longitudinal: 19h, 168h, 456h p.i.)

University of New Mexico | Mouse, SPECT/CT, Dynamic/Gated, I-131

		Comments
		Longitudinal tumor study in a mouse using I¹³¹ (8d phys. half life, 364 keV peak) labeled I¹³¹-CLR1404 (a radioiodinated phospholipid ether analog), imaged 19 hours (left) and 7 days (middle) and 19 days (right) post injection. At times of acquisition, the mouse contained as little as 11 MBq (300 µCi) of I¹³¹. However, even weeks later, the uptake in the tumor is still clearly detectable, thus allowing for longitudinal studies, tracking the development of tumors in individual animals. Despite the high energy of the I¹³¹ photons and the low activity, there is a strong signal of the tumor visible in all images. In the right image, a post-processing smoothing filter was applied (Gauss, 2 mm FWHM). For more details on the tracer see: http://cellectar.com/sciences/ Imaged at the UNM for Cellectar, LLC
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